IRS1 anticorps (pTyr632) (Biotin)

N° du produit ABIN6983062

Cet anticorps Lapin Polyclonal détecte spécifiquement IRS1 dans IHC (p). Il présente une réactivité envers Humain, Souris, Rat, Porc, Lapin, Chien, Boeuf (Vache) et Mouton.

Aperçu rapide pour IRS1 anticorps (pTyr632) (Biotin) (ABIN6983062)

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Reactivité: Humain, Souris, Rat, Porc, Lapin, Chien, Boeuf (Vache), Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRS1 est conjugé à/à la Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IRS1 anticorps (Biotin)

Épitope: pTyr632

Réactivité croisée: Boeuf (Vache), Chien, Humain, Souris, Porc, Lapin, Rat, Mouton

Purification: Purified by Protein A.

Immunogène: KLH conjugated Synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Tyr632

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur IRS1

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Autre désignation: IRS1

Sujet:

Synonyms: IRS1 (phospho Tyr632), IRS1 (phospho Y632), p-IRS1 (phospho Y632), HIRS 1, HIRS1, Insulin Receptor Substrate 1, IRS 1, IRS-1, IRS1, IRS1_HUMAN, OTTHUMP00000164234.

Background: Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

ID gène: 3667

UniProt: P35568

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process